Immune system disorders .. The failure of pregnancy in women leads to frequent miscarriage and "immune sterility". Jeddah: Dr. Abdul Hafeez Khoja Studies of healthy couples in which a woman gets pregnant easily and then suffers later from pregnancy loss through repeated miscarriage have shown that she produces fetuses that are misinterpreted by the mother''s immune system. The immune cells deal with these embryos as foreign bodies or cells, which leads to resistance, rejection and then ping them instead of adapting to them to make pregnancy a success. In these cases, various statements come to the ears of infertility patients, which need explanation and clarification, including:
It is the will of the Creator.
You were lean this time, try again. The child was an anomaly or a distortion. The body knows when it needs to reject a child. We will try to use hormones in larger doses. If you miscarry too much we''ll try IVF. The eggs or the sperm are very weak.
Next time we''ll try aspirin and heparin
Pregnancy failure spoke to Asharq Al-Awsat Prof. Dr. Emad Abdel-Qader Koshak, Associate Professor at the Faculty of Medicine - King Abdulaziz University and Medical Supervisor of the Immunology (Laboratory) Laboratory, holder of the American Board and the Royal Canadian Fellowship, the first Saudi consultant for internal diseases, allergies, asthma and immunology, member The American and European Society for Reproductive Immunology and Fertility, on this thorny and thorny issue in the lives of couples who suffer from such a problem. He reported that between 10-20% of pregnant women suffer from failure of pregnancy or sterility, through repeated pregnancy loss (miscarriage) or the failure to form the fetus at all. This has become a global phenomenon, and many recent researches indicate the role of the pregnant mother''s immune system in the success of pregnancy and the completion of the growth and development of the fetus. Every attempt to conceive a fetus that is rejected makes the problem worse. As if the womb behaves like a lion''s den, every attempt to conceive will fail. This rejection occurs even through an artificial pregnancy with healthy fetuses that have been fertilized outside the womb in test tubes (in vitro fertilization). Recent statistics for such cases indicate that there may be additional options. Most types of immune system disorders can be detected in more than 40% of recurrent pregnancy loss.
What is the typical case of immune sterility? Prof. Dr. Imad Koshak explained that the average age of patients with immune infertility ranges between 36 and 40 years. And often, they have had several unsuccessful pregnancy attempts or repeated miscarriages (4 times the rate), either after a normal pregnancy or IVF. Often these women have lost hope, due to their approaching the end of their reproductive life, and due to the negative psychological effects and experiences of material exploitation. These couples can be helped to discover something wrong with the immune system, using modern laboratory methods in clinical immunology laboratories.
Immune disorders What are the types of immune disorders? The immune problems that may cause pregnancy loss and infertility can be categorized based on the presence of two main types of immune changes in the mother:
First: Autoimmunity: It is the attack of the mother''s immune system to parts of the fetus from the mother, through:
Antibodies against the molecules of fatty phosphates (phospholipids) on the surface of cells, which act as glue to implant the fetus in the uterus and to form the placenta. Antibodies against the DNA inside the cells of the fetus. Antibodies against the thyroid gland. Antibodies against female hormones.
Increased immune B cells (B cell CD19 + 5 +) that may produce antibodies.
Second: Immunity to the other: It attacks the mother''s immune system to the parts of the fetus that are from the father, through:
Similarity or similarity in some genetic genes of both spouses (especially DQ alpha), as this causes a lack of antibodies preventing pregnancy fall in the wife and pregnancy fails.
Antibodies against the husband''s sperm. Increased natural killer cells that attack and destroy fetus cells 16+ (NKC CD56.
Secretion of fetal toxic substances from the mother''s immune cells. Immunopathology can help a lot in identifying one of the classes of immune attack causing fetal loss. There are modern and sophisticated laboratory analyzes of the immune system that can save a lot of money and eliminate many unnecessary blood tests in diagnosing the immune problem. If the immune causes are detected and identified, then appropriate treatment can be given.
Treatment Immune infertility is treated by administering a group of drugs, combined or individual, including: - Drugs that suppress or depress the immune system (prednisone).
Anti-inflammatory drugs (such as aspirin).
Anti-blood-clotting drugs.
Antibody therapy (immunoglobulin).
The use of modern industrial means of carrying. Although the amount of information on knowledge of the causes of infertility and miscarriage is large, the true causes of many immune system disorders are still unknown. The question is will food and the means of modern life have an important role in that! This will remain subject to scientific research.
