Important
It is possible that the main title of the report Neonatal-onset Multisystem Inflammatory Disease is not the name you expected. Please check the synonyms listing to find the nate name(s) and disorder subdivision(s) covered by this report.
Synonyms
NOMID
CINCA
chronic, infantile, neurological, cutaneous and articular syndrome
Disorder Subdivisions
None
General Discussion
Neonatal-onset multisystem inflammatory disease (NOMID), also known as chronic infantile neurologic cutaneous articular (CINCA) syndrome, is a rare, congenital, systemic, inflammatory condition distinguished by fever, rash, joint disease, and central nervous system (CNS) disease. The hallmark of NOMID is onset during infancy or early childhood.
NOMID is the most severe form of the cryopyrin associated periodic syndromes (CAPS) caused by mutations in the CIAS1/NLRP3 gene. These syndromes are characterized by fever, rash, and joint pain.
