Researchers say that lack of sleep affects the functions of genes related to pressure and cell regeneration, which may negatively affect the overall health of the body. Of course, doctors realize that every person who suffers from chronic sleep deprivation puts his body at great health risks. Employees who work at night and all people who get insufficient sleep at night are more likely to get obesity and suffer from cardiovascular disease compared to those who get enough and good sleep every night, according to many research and scientific studies. It appears that the chain of consequences of sleep deprivation is still open to other diseases and ills, as researchers discovered that lack of sleep harms an increasing number of body functions, including genetics, according to a recent study published in the latest issue of the Journal of the National Academy of Sciences.
Researchers involved 26 volunteers in a study during which they were deprived of a sufficient amount of sleep for seven consecutive nights, after which they monitored many changes in the way the behavior and performance of hundreds of genes within the bodies of the participating volunteers. They also found that some genes are enlarged and hyperactive, including those that induce stress when exposed to stress. They also recorded that some of them decreased, including genes that feed and regenerate cells and tissues.
Poor quality
"The impact of lack of sleep on the deterioration of body health is evident in the way many functions are performed," said Dr. Colin Smith, a genomics researcher from the University of Surrey in England.
Dr. Dirk Jan Dijk, a sleep and rhythm specialist in the body''s biological clock at the University of Surrey English, says, “Scientists and researchers have always been confused about the correlation between sleep and health. In contemporary history, they spent several years studying the effect of sleep quality on the brain. However, epidemiologists have noted, on the other hand, that people who work in the early morning hours or late hours of the night, or those who suffer from lack of sleep in general, are exposed to higher rates of diabetes, strokes, high blood pressure, and other ills. Biologists have discovered that the bodies of people of poor quality sleep produce more quantities of stress hormones known as cortisol, the appetite hormones "ghrelin", as well as other biochemical changes.
The researcher at Harvard Medical School, famous for his research on the impact of poor quality of sleep on a person in every aspect of his daily life, Dr. Charles Ziessler, said, "There was previously a belief that sleep comes from the brain and is implemented in the interest of the brain. Today, all sleep disorders specialists know that sleep plays an important role in determining the effectiveness of body functions. ”
A series of tests
In order to learn more about sleep-related mechanical mechanisms and mechanisms, scientists, Digic and Smith and their colleagues asked the volunteers participating in their study to fill out two types of evaluation forms, each covering 12 days. In one of the examinations and tests of the participants, who are all adults who have never suffered from any sleep disturbance, they were allowed to sleep in bed for ten hours during seven consecutive nights. The examination of the waves that underwent their brains showed that their average sleep rate was 8.5 hours every night, which is an adequate daily allowance.
In another test, the participants were allowed to stay in their sleep beds for six hours for seven consecutive nights, and their brains showed that their average sleep rate was 5.7 hours each day.
At the end of each week of the observed sleep rations, the researchers asked the participants to remain awake for a continuous period ranging between 39 and 41 hours, during which they were taking blood samples from each of them for analysis every three hours, until the samples drawn from each Participant: 10 samples. Then the researchers analyzed the blood cells, and compared the changes that occurred in the level of the RNA molecules that carry the instructions of the DNA. The proteins that lead to all the processes that happen in the body.
After this series of examinations and tests, the researchers found that lack of sleep s the rhythmic patterns of the way genes are activated and suppressed, and the functioning of genes is disturbed at the biological clock level, and some may be damaged.
Quick effects
At the conclusion of the study, the researchers found that 711 genes were expressed in different ways when participants were deprived of sleep. The performance of 444 genes decreased, while the performance of only 277 genes increased. Other analyzes conducted by the researchers revealed that the genes responsible for inflammation, immunity and damage to proteins were activated after they were activated, which means that tissue damage and damage occurred after the body was subjected to sleep deprivation.
In contrast, many of the genes that disordered and performed contributed to the secretion of new proteins, cells and tissues. It seemed to researchers clearly that the process of balance tissue regeneration was subjected to disruption and disturbance immediately after the body suffered from a lack of sleep. Digic and Smith said they were surprised by the rapid effects of changes in the bodies of the participants after a short period of sleep deprivation of no more than one week.
According to the Centers for Disease Control and Prevention, 30% of American adult civilians say they sleep six hours or less per day. This indicates that millions of Americans are damaging the tissues of their bodies and cells. Scientists who did not participate in the study praised the researchers ’findings, and praised the methodology used in it and the well-designed stages. They also stated that the ability to assess the molecular effects of sleep deprivation represents a promising progress in the field of research and studies that take up the subject of sleep.
Self-evaluation
Several studies have been conducted on the biological effects of sleep deprivation in laboratory laboratories that include experimental animals, such as mice. Scientists have studied gene expressions in tissues, from the brain or from the liver. But later research has shown that gene expressions in mice do not apply to human gene expressions for several reasons. Nevertheless, it must be said that the ability to use a simple blood test to find out the effect of sleep deprivation on the functions of body organs is an important achievement to be calculated by researchers, according to Dr. Zeissler, who was not a member of the British researchers'' team.
At the present time, doctors should rely on the patient''s self-assessment of how tired, tired, or tired he is due to lack of sleep. But, according to Zeissler, people are under the illusion that the caffeine impression that they have overcome sleep deprivation and regained their vitality and vitality is a false and imaginary impression that the body pays dearly by increasing its tissue susceptibility to damage and impairment, and the decline in its functioning and weakening immunity.
